Causal relationship between basal metabolic rate and intervertebral disc degeneration: a Mendelian randomization study.
Eur Spine J
; 33(9): 3352-3358, 2024 Sep.
Article
in En
| MEDLINE
| ID: mdl-38910168
ABSTRACT
BACKGROUND:
The role of basal metabolic rate (BMR) in intervertebral disc degeneration (IVDD) is still uncertain. To address this gap, we conducted a Mendelian randomization (MR) study to comprehensively explore the causal relationship between BMR and IVDD.METHODS:
BMR data were obtained from a large genome-wide association study (GWAS) database, while IVDD data were derived from the FinnGen project. The causal relationship between IVDD and BMR was investigated using MR, with inverse-variance weighting (IVW) as the primary estimate. MR-Egger weighed median and weighed mode were employed for robustness. Sensitivity analyses, including the Cochran Q test, leave-one-out analysis, and MR-Egger intercept analysis, were conducted. Furthermore, the study also identified causal relationships between IVDD and factors associated with BMR (hyperthyroidism, type 2 diabetes, standing height, weight, and body mass index). Multivariable MR was applied to further assess the direct effect of BMR on IVDD.RESULTS:
Genetic predisposition to BMR (after removing outliers OR 1.49; 95% CI 1.37-1.63; P = 5.073e-21) were associated with an increased risk of IVDD. Additionally, IVDD risk increased with greater height, weight, and BMI. No causal relationship was observed between hy/thy and T2D and intervertebral disc degeneration (IVDD) (P > 0.05). In multivariable MR, a significant causal association between BMR and IVDD persisted, even after adjusting for BMI, height, and weight.CONCLUSION:
In this study, we successfully identified that a higher BMR is independently and causally linked to IVDD, indicating an increased risk of developing IVDD. These findings suggest that managing BMR could potentially mitigate the risk of IVDD.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Basal Metabolism
/
Genome-Wide Association Study
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Intervertebral Disc Degeneration
/
Mendelian Randomization Analysis
Limits:
Female
/
Humans
/
Male
Language:
En
Journal:
Eur Spine J
/
Eur. spine j
/
European spine journal
Journal subject:
ORTOPEDIA
Year:
2024
Document type:
Article
Affiliation country:
China
Country of publication:
Alemania