Nontopical Nitrates in Flap Perfusion and Delay Phenomenon.
Plast Reconstr Surg Glob Open
; 12(6): e5918, 2024 Jun.
Article
in En
| MEDLINE
| ID: mdl-38911578
ABSTRACT
Background:
Topical nitrates have demonstrated efficacy in improving flap perfusion. However, evidence for nontopical nitrates in modulation of flap perfusion dynamics has yet to be consolidated. Here, we review evidence regarding the use of intravascular, sublingual, and oral nitrates in modulating flap perfusion.Methods:
We performed a review of the literature for evidence linking nontopical nitrates and flap perfusion, and included clinical studies, animal studies, and in vitro studies.Results:
Evidence suggests that intravascular, sublingual, and oral nitrates exert vasodilatory properties, which may be harnessed for identification of perforators and improved flap perfusion. We also found evidence suggesting nitrates may facilitate ischemic preconditioning while reducing ischemia-reperfusion injury.Conclusions:
Nitrates delivered intravascularly, sublingually, or orally may increase flap perfusion and serve as a method for ischemic preconditioning, particularly in the intraoperative setting.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Plast Reconstr Surg Glob Open
Year:
2024
Document type:
Article
Affiliation country:
Laos