Mesenchymal stem cell-derived exosomes as cell free nanotherapeutics and nanocarriers.
Nanomedicine
; 61: 102769, 2024 Oct.
Article
in En
| MEDLINE
| ID: mdl-38914247
ABSTRACT
Many strategies for regenerating the damaged tissues or degenerating cells are employed in regenerative medicine. Stem cell technology is a modern strategy of the recent approaches, particularly the use of mesenchymal stem cells (MCSs). The ability of MSCs to differentiate as well as their characteristic behaviour as paracrine effector has established them as key elements in tissue repair. Recently, extracellular vesicles (EVs) shed by MSCs have emerged as a promising cell free therapy. This comprehensive review encompasses MSCs-derived exosomes and their therapeutic potential as nanotherapeutics. We also discuss their potency as drug delivery nano-carriers in comparison with liposomes. A better knowledge of EVs behaviour in vivo and of their mechanism of action are key to determine parameters of an optimal formulation in pilot studies and to establish industrial processes.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Exosomes
/
Mesenchymal Stem Cells
Limits:
Animals
/
Humans
Language:
En
Journal:
Nanomedicine
Journal subject:
BIOTECNOLOGIA
Year:
2024
Document type:
Article
Affiliation country:
Francia
Country of publication:
Estados Unidos