Challenges in genetic screening for inherited endocrinopathy affecting the thyroid, parathyroid and adrenal glands in Singapore.
Ann Acad Med Singap
; 53(4): 253-263, 2024 Apr 29.
Article
in En
| MEDLINE
| ID: mdl-38920182
ABSTRACT
Significant progress has been made in the understand-ing of many human diseases, especially cancers, which has contributed to improved and increased survival. The Human Genome Project and The Cancer Genome Atlas project brought about a new era, with an understanding of inherited diseases at a molecular level, which subsequently facilitated the option of precision medicine. Precision medicine has helped tailor treatment decisions at an individual level, for instance in terms of surgical treatments or targeted therapies in advanced diseases. Despite the increasing advances in genetic-lead precision medicine, this has not translated into increasing uptake among patients. Reasons for this may be potential knowledge gaps among clinicians; on reasons for poor uptake of genetic testing such as for cultural, religious or personal beliefs; and on financial implications such as lack of support from insurance companies. In this review, we look at the current scenario of genetic screening for common inherited endocrine conditions affecting the thyroid, parathyroid and adrenal glands in Singapore, and the implications associated with it.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Genetic Testing
Limits:
Humans
Country/Region as subject:
Asia
Language:
En
Journal:
Ann Acad Med Singap
/
Ann. Acad. Med. Singap. (Online)
/
Annals, Academy of Medicine, Singapore (Online)
Year:
2024
Document type:
Article
Affiliation country:
Singapur
Country of publication:
Singapur