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An Overview of the Synthesis of 3,4-Fused Pyrrolocoumarins of Biological Interest.
Kapidou, Eleni; Litinas, Konstantinos E.
Affiliation
  • Kapidou E; Laboratory of Organic Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
  • Litinas KE; Laboratory of Organic Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Molecules ; 29(12)2024 Jun 09.
Article in En | MEDLINE | ID: mdl-38930816
ABSTRACT
3,4-Fused pyrrolocoumarins, synthetically prepared or naturally occurring, possess interesting biological properties. In this review, the synthetic strategies for the synthesis of the title compounds are presented along with their biological activities. Two routes are followed for that synthesis. In one, the pyrrole ring is formed from coumarin derivatives, such as aminocoumarins or other coumarins. In the other approach, the pyranone moiety is built from an existing pyrrole derivative or through the simultaneous formation of coumarin and pyrrole frameworks. The above syntheses are achieved via 1,3-dipolar cycloaddition reactions, Michael reaction, aza-Claisen rearrangement reactions, multi-component reactions (MCR), as well as metal-catalyzed reactions. Pyrrolocoumarins present cytotoxic, antifungal, antibacterial, α-glucosidase inhibition, antioxidant, lipoxygenase (LOX) inhibition, and fluorescent activities, as well as benzodiazepine receptor ability.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrroles / Coumarins Limits: Humans Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2024 Document type: Article Affiliation country: Grecia Country of publication: Suiza

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrroles / Coumarins Limits: Humans Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2024 Document type: Article Affiliation country: Grecia Country of publication: Suiza