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Developing guanine base editors for G-to-T editing in rice.
Liu, Lang; Zhang, Zhongming; Wang, Chenyang; Yan, Fang; Sun, Wenxian; Zhou, Xueping; Miao, Weiguo; Zhou, Huanbin.
Affiliation
  • Liu L; State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, 100193, China.
  • Zhang Z; Department of Plant Pathology, China Agricultural University, Beijing, 100193, China.
  • Wang C; Scientific Observing and Experimental Station of Crop Pests in Guilin, Ministry of Agriculture and Rural Affairs, Guilin, 541399, China.
  • Yan F; State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, 100193, China.
  • Sun W; School of Plant Protection, Hainan University, Haikou, 570228, China.
  • Zhou X; State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, 100193, China.
  • Miao W; State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, 100193, China.
  • Zhou H; Department of Plant Pathology, China Agricultural University, Beijing, 100193, China.
J Integr Plant Biol ; 66(8): 1557-1560, 2024 Aug.
Article in En | MEDLINE | ID: mdl-38934772
ABSTRACT
Two guanine base editors created using an engineered N-methylpurine DNA glycosylase with CRISPR systems achieved targeted G-to-T editing with 4.94-12.50% efficiency in rice (Oryza sativa). The combined use of the DNA glycosylase and deaminases enabled co-editing of target guanines with adenines or cytosines.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oryza / Gene Editing / Guanine Language: En Journal: J Integr Plant Biol Year: 2024 Document type: Article Affiliation country: China Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oryza / Gene Editing / Guanine Language: En Journal: J Integr Plant Biol Year: 2024 Document type: Article Affiliation country: China Country of publication: