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Stereoelectroencephalography of the Deep Brain: Basal Ganglia and Thalami.
Pati, Sandipan; Agashe, Shruti; Kheder, Ammar; Riley, Kristen; Gavvala, Jay; McGovern, Robert; Suresh, Surya; Chaitanya, Ganne; Thompson, Stephen.
Affiliation
  • Pati S; Texas Comprehensive Epilepsy Program, Department of Neurology, The University of Texas Health Science Center at Houston, Texas, U.S.A.
  • Agashe S; Department of Neurology, Duke Comprehensive Epilepsy Center, Duke University, Durham, North Carolina, U.S.A.
  • Kheder A; Department of Neurology, Children's Healthcare of Atlanta, Emory University, Atlanta, Georgia, U.S.A.
  • Riley K; Department of Neurosurgery, Heersink School of Medicine, University of Alabama at Birmingham, Alabama, U.S.A.
  • Gavvala J; Texas Comprehensive Epilepsy Program, Department of Neurology, The University of Texas Health Science Center at Houston, Texas, U.S.A.
  • McGovern R; Department of Neurosurgery, University of Minnesota, Minnesota, U.S.A.; and.
  • Suresh S; Texas Comprehensive Epilepsy Program, Department of Neurology, The University of Texas Health Science Center at Houston, Texas, U.S.A.
  • Chaitanya G; Texas Comprehensive Epilepsy Program, Department of Neurology, The University of Texas Health Science Center at Houston, Texas, U.S.A.
  • Thompson S; Neurology Division of the Department of Medicine, Hamilton Health Sciences and McMaster University, Canada.
J Clin Neurophysiol ; 41(5): 423-429, 2024 Jul 01.
Article in En | MEDLINE | ID: mdl-38935656
ABSTRACT

SUMMARY:

Stereoelectroencephalography (SEEG) has emerged as a transformative tool in epilepsy surgery, shedding light on the complex network dynamics involved in focal epilepsy. This review explores the role of SEEG in elucidating the role of deep brain structures, namely the basal ganglia and thalamus, in epilepsy. SEEG advances understanding of their contribution to seizure generation, propagation, and control by permitting precise and minimally invasive sampling of these brain regions. The basal ganglia, comprising the subthalamic nucleus, globus pallidus, substantia nigra, and striatum, have gained recognition for their involvement in both focal and generalized epilepsy. Electrophysiological recordings reveal hyperexcitability and increased synchrony within these structures, reinforcing their role as critical nodes within the epileptic network. Furthermore, low-frequency and high-frequency stimulation of the basal ganglia have demonstrated potential in modulating epileptogenic networks. Concurrently, the thalamus, a key relay center, has garnered prominence in epilepsy research. Disrupted thalamocortical connectivity in focal epilepsy underscores its significance in seizure maintenance. The thalamic subnuclei, including the anterior nucleus, centromedian, and medial pulvinar, present promising neuromodulatory targets, suggesting pathways for personalized epilepsy therapies. The prospect of multithalamic SEEG and thalamic SEEG stimulation trials has the potential to revolutionize epilepsy management, offering tailored solutions for challenging cases. SEEG's ability to unveil the dynamics of deep brain structures in epilepsy promises enhanced and personalized epilepsy care in our new era of precision medicine. Until deep brain SEEG is accepted as a standard of care, a rigorous informed consent process remains paramount for patients for whom such an exploration is proposed.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thalamus / Basal Ganglia / Electroencephalography Limits: Humans Language: En Journal: J Clin Neurophysiol Journal subject: FISIOLOGIA / NEUROLOGIA Year: 2024 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thalamus / Basal Ganglia / Electroencephalography Limits: Humans Language: En Journal: J Clin Neurophysiol Journal subject: FISIOLOGIA / NEUROLOGIA Year: 2024 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos