Regulation of 3D genome organization during T cell activation.
FEBS J
; 2024 Jun 29.
Article
in En
| MEDLINE
| ID: mdl-38944686
ABSTRACT
Within the three-dimensional (3D) nuclear space, the genome organizes into a series of orderly structures that impose important influences on gene regulation. T lymphocytes, crucial players in adaptive immune responses, undergo intricate transcriptional remodeling upon activation, leading to differentiation into specific effector and memory T cell subsets. Recent evidence suggests that T cell activation is accompanied by dynamic changes in genome architecture at multiple levels, providing a unique biological context to explore the functional relevance and molecular mechanisms of 3D genome organization. Here, we summarize recent advances that link the reorganization of genome architecture to the remodeling of transcriptional programs and conversion of cell fates during T cell activation and differentiation. We further discuss how various chromatin architecture regulators, including CCCTC-binding factor and several transcription factors, collectively modulate the genome architecture during this process.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
FEBS J
/
FEBS j
/
FEBS journal
Journal subject:
BIOQUIMICA
Year:
2024
Document type:
Article
Affiliation country:
China
Country of publication:
Reino Unido