FAK inhibitors in cancer, a patent review - an update on progress.
Expert Opin Ther Pat
; 34(8): 593-610, 2024 Aug.
Article
in En
| MEDLINE
| ID: mdl-38946486
ABSTRACT
INTRODUCTION:
Focal adhesion kinase (FAK) is a cytoplasmic non-receptor tyrosine kinase over-expressed in various malignancies which is related to various cellular functions such as adhesion, metastasis and proliferation. AREAS COVERED There is growing evidence that FAK is a promising therapeutic target for designing inhibitors by regulating the downstream pathways of FAK. Some potential FAK inhibitors have entered clinical phase research. EXPERT OPINION FAK could be an effective target in medicinal chemistry research and there were a variety of FAKIs have been patented recently. Here, we updated an overview of design, synthesis and structure-activity relationship of chemotherapeutic FAK inhibitors (FAKIs) from 2017 until now based on our previous work. We hope our efforts can broaden the understanding of FAKIs and provide new ideas and insights for future cancer treatment from medicinal chemistry point of view.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Patents as Topic
/
Drug Design
/
Protein Kinase Inhibitors
/
Focal Adhesion Protein-Tyrosine Kinases
/
Neoplasms
/
Antineoplastic Agents
Limits:
Animals
/
Humans
Language:
En
Journal:
Expert Opin Ther Pat
Journal subject:
TERAPEUTICA
Year:
2024
Document type:
Article
Country of publication:
Reino Unido