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Comparison of transfer of different sulphonamides from contaminated beeswax to honey.
Mitrowska, Kamila; Antczak, Maja.
Affiliation
  • Mitrowska K; Department of Pharmacology and Toxicology, National Veterinary Research Institute, 24-100 Pulawy, Poland.
  • Antczak M; Department of Pharmacology and Toxicology, National Veterinary Research Institute, 24-100 Pulawy, Poland.
J Vet Res ; 68(2): 249-254, 2024 Jun.
Article in En | MEDLINE | ID: mdl-38947155
ABSTRACT

Introduction:

No maximum residue limits in honey have been legislated in the EU for antimicrobial substances such as sulphonamides, and they are not permitted, therefore, for treating honey bees unless in a cascade system. Since sulphonamides are used illegally in apiculture to treat foulbrood, their residues can be found in honey and other apiculture products, including beeswax. The study aimed to assess the contamination of honey from beeswax containing residues of 10 sulphonamides (sulphadimethoxine (SDM), sulphadoxine (SDX), sulphamonomethoxine (SMM), sulphamethoxazole (SMX), sulphameter (SMT), sulphamethazine (SMZ), sulphamerazine (SMR), sulphadiazine (SDA), sulphathiazole (STZ) and sulphacetamide (SCA)). Material and

Methods:

Wax-based foundations fortified with 10 sulphonamides at 10,000 µg/kg were evaluated for sulphonamide concentrations and then placed in a beehive so that honey bees (Apis mellifera L.) could build honeycombs with them. Frames of capped honey were taken out of the hives one month later and honey was sampled from them. The honeycombs were subsequently incubated in a laboratory at 35°C for five months, and honey was sampled monthly. The honey sulphonamide concentrations were measured using liquid chromatography-tandem mass spectrometry and compared to the wax-based foundation concentrations.

Results:

The maximum transfers to honey of the initial amount of SDM, SDX, SMM, SMX, SMT, SMZ, SMR, SDA, STZ and SCA in the wax-based foundations were 42.6, 34.3, 31.7, 30.1, 29.5, 25.2, 18.7, 16.1, 9.5 and 8.6%, respectively.

Conclusion:

This study demonstrated that every tested sulphonamide could migrate from beeswax in antimicrobial-tainted honeycombs to honey, SDM having the highest migration potential and SCA the lowest.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: J Vet Res Year: 2024 Document type: Article Affiliation country: Polonia

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: J Vet Res Year: 2024 Document type: Article Affiliation country: Polonia