A little ER stress isn't bad: the IRE1α/XBP1 pathway shapes ILC3 functions during intestinal inflammation.
J Clin Invest
; 134(13)2024 Jul 01.
Article
in En
| MEDLINE
| ID: mdl-38949019
ABSTRACT
Type 3 innate lymphoid cells (ILC3s) are key regulators of intestinal homeostasis and epithelial barrier integrity. In this issue of the JCI, Cao and colleagues found that a sensor of endoplasmic reticulum (ER) stress, the inositol-requiring kinase 1α/X-box-binding protein 1 (IRE1α/XBP1) pathway, fine-tuned the functions of ILC3s. Activation of IRE1α and XBP1 in ILC3s limited intestinal inflammation in mice and correlated with the efficacy of ustekinumab, an IL-12/IL-23 blocker, in patients with Crohn's disease. These results advance our understanding in the use of ILCs as biomarkers not only to predict disease outcomes but also to indicate the response to biologicals in patients with inflammatory bowel disease.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Protein Serine-Threonine Kinases
/
Endoribonucleases
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Endoplasmic Reticulum Stress
/
X-Box Binding Protein 1
Limits:
Animals
/
Humans
Language:
En
Journal:
J Clin Invest
/
J. clin. invest
/
Journal of clinical investigation
Year:
2024
Document type:
Article
Affiliation country:
Italia
Country of publication:
Estados Unidos