Poissonian Cellular Potts Models Reveal Nonequilibrium Kinetics of Cell Sorting.
Phys Rev Lett
; 132(24): 248401, 2024 Jun 14.
Article
in En
| MEDLINE
| ID: mdl-38949349
ABSTRACT
Cellular Potts models are broadly applied across developmental biology and cancer research. We overcome limitations of the traditional approach, which reinterprets a modified Metropolis sampling as ad hoc dynamics, by introducing a physical timescale through Poissonian kinetics and by applying principles of stochastic thermodynamics to separate thermal and relaxation effects from athermal noise and nonconservative forces. Our method accurately describes cell-sorting dynamics in mouse-embryo development and identifies the distinct contributions of nonequilibrium processes, e.g., cell growth and active fluctuations.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Stochastic Processes
/
Models, Biological
Limits:
Animals
Language:
En
Journal:
Phys Rev Lett
Year:
2024
Document type:
Article
Affiliation country:
Alemania