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In vitro anti-breast cancer study of hybrid cinnamic acid derivatives bearing 2-thiohydantoin moiety.
Binjawhar, Dalal Nasser; Al-Salmi, Fawziah A; Alghamdi, Maha Ali; Abu Ali, Ola A; Fayad, Eman; Rizzk, Youstina William; Ali, Nourhan M; El-Deen, Ibrahim Mohey; Eltamany, Elsayed H.
Affiliation
  • Binjawhar DN; Department of Chemistry, College of science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia.
  • Al-Salmi FA; Biology Department, College of Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
  • Alghamdi MA; Department of Biotechnology, College of Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
  • Abu Ali OA; Department of Chemistry, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
  • Fayad E; Department of Biotechnology, College of Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
  • Rizzk YW; Department of Chemistry (The Division of Biochemistry), Faculty of Science, Port Said University, Port Said, Egypt.
  • Ali NM; Department of Chemistry, Faculty of Science, Suez Canal University, Ismailia, Egypt.
  • El-Deen IM; Department of Chemistry (The Division of Organic Chemistry), Faculty of Science, Port Said University, Port Said, Egypt.
  • Eltamany EH; Department of Chemistry, Faculty of Science, Suez Canal University, Ismailia, Egypt.
Future Med Chem ; : 1-20, 2024 Jul 01.
Article in En | MEDLINE | ID: mdl-38949859
ABSTRACT

Aim:

 To synthesize new hybrid cinnamic acids (10a, 10b and 11) and ester derivatives (7, 8 and 9) and investigate their anti-breast cancer activities. Materials &

methods:

Compounds 7-11 were evaluated (in vitro) for their cytotoxic activities against the MCF-7 cell line. A flow cytometry examination was performed. Protein levels of nuclear factor erythroid 2-related factor 2 (Nrf2), topoisomerase II and caspase-9 were measured by qRT-PCR. Molecular docking studies were conducted.

Results:

Several components were discovered to be active, mainly component 11, which induced arrest in the cell cycle at phase S, greatly decreased the expression of Nrf2 and topoisomerase II; and upregulated the expression of caspase-9.

Conclusion:

The newly thiohydantoin-cinnamic acid hybrids can contribute to creating promising candidates for cancer drugs.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Future Med Chem Year: 2024 Document type: Article Affiliation country: Arabia Saudita
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Future Med Chem Year: 2024 Document type: Article Affiliation country: Arabia Saudita