Plasma proteins and inflammatory dermatoses: proteome-wide Mendelian randomization and colocalization analyses.
Arch Dermatol Res
; 316(7): 443, 2024 Jul 01.
Article
in En
| MEDLINE
| ID: mdl-38951247
ABSTRACT
Current genome-wide association studies (GWAS) of plasma proteomes provide additional possibilities for finding new drug targets for inflammatory dermatoses. We performed proteome-wide Mendelian randomization (MR) and colocalization analyses to identify novel potential drug targets for inflammatory dermatoses. We performed MR and colocalization analysis using genetic variation as instrumental variables to determine the causal relationship between circulating plasma proteins and inflammatory dermatoses. 5 plasma proteins were found to be causally associated with dermatitis eczematosa, SLE, urticaria and psoriasis using cis-pQTLs as instrumental variables, but not found in AD and LP. 19 candidate genes with high colocalization evidence were identified. These potential drug targets still require more research and rigorous validation in future trials.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Blood Proteins
/
Proteome
/
Genome-Wide Association Study
/
Mendelian Randomization Analysis
Limits:
Humans
Language:
En
Journal:
Arch Dermatol Res
Year:
2024
Document type:
Article
Affiliation country:
China