The effect of cyclosporine a in pterygium surgery using fibrin glue.
Int Ophthalmol
; 44(1): 297, 2024 Jun 29.
Article
in En
| MEDLINE
| ID: mdl-38951293
ABSTRACT
BACKGROUND/OBJECTIVES:
To evaluate the effect of topical cyclosporine A (CsA) 0.05% in patients with pterygium surgery using fibrin glue (FG). SUBJECTS/METHODS:
Patients with primary nasal pterygium were retrospectically analyzed and categorized into two groups Group 1 with 41 eyes from 38 patients as a control group and group 2 with 39 eyes from 36 patients who received topical CsA twice a day for 6 months. Patients were assessed for recurrence rate, tear film parameters, side effects, and complications at postoperative intervals of 1-7 days; 1st, 3rd, 6th and 12th months. The follow-up period was 1 year.RESULTS:
The two groups were age (p = 0.934) and sex (p = 0.996) matched. CsA drop was discontinued in one patient due to burning sensation and conjunctival hyperemia after 1 week. There was no statistically significant difference between the mean preoperative and postoperative 1st year Schirmer I and tear break-up time (TBUT) values in group 1 (p = 0.136; p = 0.069). Although the difference between the mean preoperative and postoperative 1st year TBUT values in group 2 was not statistically different (p = 0.249), Schirmer I results were higher postoperatively (p = 0.003). There was no statistically significant difference between preoperative Schirmer (p = 0.496), postoperative Schirmer (p = 0.661), preoperative TBUT (p = 0.240) and postoperative TBUT (p = 0.238) results of the two groups. Recurrence was observed in only one patient from group 1.CONCLUSION:
No recurrent pterygium cases were observed in group 2. Schirmer I values were higher postoperatively in group 2; thus,topical CsA treatment may improve lacrimal secretion and be effective after pterygium surgery with FG.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pterygium
/
Fibrin Tissue Adhesive
/
Cyclosporine
/
Immunosuppressive Agents
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Int Ophthalmol
Year:
2024
Document type:
Article
Affiliation country:
Turquía