Fluoride-Mediated Aryne 1,2-Difunctionalization Involving CâS Bond Heterolysis.
J Org Chem
; 89(14): 10047-10053, 2024 Jul 19.
Article
in En
| MEDLINE
| ID: mdl-38951997
ABSTRACT
We have successfully synthesized a series of bidentate ligands by utilizing 2-(trimethylsilyl)phenyl trifluorosulfonate as a precursor for the benzyl group. This method proceeded by inserting a polythiourea into the CâS π-bond, intramolecular ring proton migration, and ring opening. Salient features of this strategy are mild reaction conditions, a novel product structure, excellent stereochemistry, and a good functional group tolerance. Furthermore, a series of density functional theory calculations were performed to gain insights into the transfer mechanism.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
J Org Chem
Year:
2024
Document type:
Article
Affiliation country:
China
Country of publication:
Estados Unidos