Oleuropein mitigates non-alcoholic fatty liver disease (NAFLD) and modulates liver metabolites in high-fat diet-induced obese mice via activating PPARα.
J Sci Food Agric
; 104(14): 8634-8645, 2024 Nov.
Article
in En
| MEDLINE
| ID: mdl-38952322
ABSTRACT
BACKGROUND:
This study aimed to elucidate the mechanism of oleuropein (OLE) ameliorates non-alcoholic fatty liver disease (NAFLD) and its underlying mechanisms.RESULTS:
Male C57BL/6J mice were fed either a low-fat diet (LFD), a high-fat diet (HFD), or a HFD supplemented with 0.03% (w/w) OLE for 16 weeks. OLE supplementation decreased body weight and liver weight, improved serum lipid profiles, and ameliorated HFD-induced hepatic dysfunction. Liver metabolomics analysis revealed that OLE increased the levels of nicotinamide, tauroursodeoxycholic acid, taurine, and docosahexaenoic acid, which were beneficial for lipid homeostasis and inflammation regulation. OLE exerted its protective effects by activating peroxisome proliferator-activated receptor alpha (PPARα), a key transcription factor that regulates fibroblast growth factor 21 (FGF21) expression and modulates lipid oxidation, lipogenesis and inflammation pathways. Importantly, OLE supplementation did not significantly affect body weight or liver weight in PPARα knockout (PPARα KO) mice, indicating that PPARα is essential for OLE-mediated NAFLD prevention.CONCLUSION:
Our results suggest that OLE alleviates NAFLD in mice by activating PPARα and modulating liver metabolites. © 2024 Society of Chemical Industry.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
PPAR alpha
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Iridoid Glucosides
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Diet, High-Fat
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Non-alcoholic Fatty Liver Disease
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Liver
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Mice, Inbred C57BL
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Obesity
Limits:
Animals
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Humans
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Male
Language:
En
Journal:
J Sci Food Agric
/
J. sci. food agric
/
Journal of the science of food and agriculture
Year:
2024
Document type:
Article
Affiliation country:
China
Country of publication:
Reino Unido