Hypervalent iodine-catalyzed amide and alkene coupling enabled by lithium salt activation.
Beilstein J Org Chem
; 20: 1405-1411, 2024.
Article
in En
| MEDLINE
| ID: mdl-38952958
ABSTRACT
Hypervalent iodine catalysis has been widely utilized in olefin functionalization reactions. Intermolecularly, the regioselective addition of two distinct nucleophiles across the olefin is a challenging process in hypervalent iodine catalysis. We introduce here a unique strategy using simple lithium salts for hypervalent iodine catalyst activation. The activated hypervalent iodine catalyst allows the intermolecular coupling of soft nucleophiles such as amides onto electronically activated olefins with high regioselectivity.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Beilstein J Org Chem
Year:
2024
Document type:
Article
Affiliation country:
Estados Unidos