Unexpected Low Rate of Amyloid-ß Pathology in Multiple Sclerosis Patients.
Ann Neurol
; 2024 Jul 04.
Article
in En
| MEDLINE
| ID: mdl-38963256
ABSTRACT
The life expectancy of people with multiple sclerosis (MS) has increased, yet we have noted that development of a typical Alzheimer disease dementia syndrome is uncommon. We hypothesized that Alzheimer disease pathology is uncommon in MS patients. In 100 MS patients, the rate of amyloid-ß plasma biomarker positivity was approximately half the rate in 300 non-MS controls matched on age, sex, apolipoprotein E proteotype, and cognitive status. Interestingly, most MS patients who did have amyloid-ß pathology had features atypical for MS at diagnosis. These results support that MS is associated with reduced Alzheimer disease risk, and suggest new avenues of research. ANN NEUROL 2024.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Ann Neurol
Year:
2024
Document type:
Article
Affiliation country:
Estados Unidos