Vitamin D attenuates monosodium glutamate-induced behavioural anomalies, metabolic dysregulation, cholinergic impairment, oxidative stress, and astrogliosis in rats.
Neurotoxicology
; 103: 297-309, 2024 Jul.
Article
in En
| MEDLINE
| ID: mdl-38964510
ABSTRACT
BACKGROUND:
Monosodium glutamate (MSG) is a commonly used flavor enhancer that has raised concerns due to its potential adverse effects on various organs. This study explored the neuroprotective potential of Vitamin D, a beneficial micronutrient, in mitigating MSG-induced neurotoxicity. MATERIALS ANDMETHODS:
Adult male Wistar rats were categorized into five groups control (2â¯ml/kg PBS orally for 30 days), MSG (40â¯mg/kg orally for 30 days), VIT-D (oral cholecalciferol; 500 IU/kg for 30 days), MSG+VIT-D (MSG for 30 days followed by VIT-D for another 30 days), and VIT-D/MSG (concurrent VIT-D and MSG for 30 days). The rats underwent neurobehavioral, histochemical, and biochemical analyses following the treatments.RESULTS:
MSG treatment caused a decline in both long and short-term memory, along with reduced exploratory and anxiogenic behavior, mitigated by vitamin D treatment. MSG exposure also induced impaired behavior, dyslipidemia, oxidative stress, lipid peroxidation, altered cholinergic transmission, and increased chromatolysis and neuroinflammation in the frontal cortex, hippocampus, and cerebellum.CONCLUSIONS:
VIT-D demonstrated a mitigating effect on MSG-induced adverse outcomes, highlighting its potential to attenuate neurodegenerative cascades. This investigation contributes to understanding MSG-associated neurotoxicity and suggests vitamin D as a valuable and potential intervention for neuroprotection.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sodium Glutamate
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Vitamin D
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Rats, Wistar
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Oxidative Stress
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Gliosis
Limits:
Animals
Language:
En
Journal:
Neurotoxicology
Year:
2024
Document type:
Article
Country of publication:
Países Bajos