Exploring Protein Bioconjugation: A Redox-Based Strategy for Tryptophan Targeting.
Research (Wash D C)
; 7: 0410, 2024.
Article
in En
| MEDLINE
| ID: mdl-38966747
ABSTRACT
Amino acid bioconjugation technology has emerged as a pivotal tool for linking small-molecule fragments with proteins, antibodies, and even cells. The study in Nature by Chang and Toste introduces a redox-based strategy for tryptophan bioconjugation, employing N-sulfonyloxaziridines as oxidative cyclization reagents, demonstrating high efficiency comparable to traditional click reactions. Meanwhile, this tool provides feasible methods for investigating the mechanisms underlying functional tryptophan-related biochemical processes, paving the way for protein function exploration, activity-based proteomics for functional amino acid identification and characterization, and even the design of covalent inhibitors.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Research (Wash D C)
Year:
2024
Document type:
Article
Country of publication:
Estados Unidos