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Self-reported suicidal ideation among individuals with first episode psychosis and healthy controls: Findings from the international multicentre EU-GEI study.
Heuschen, C B B C M; Bolhuis, K; Zantvoord, J B; Bockting, C L; Denys, D A J P; Lok, A; Arango, C; Arrojo, M; Bernardo, M; Bobes, J; Del-Ben, C M; Di Forti, M; Gayer-Anderson, C; Jones, P B; Jongsma, H E; Kirkbride, J B; La Cascia, C; Lasalvia, A; Tosato, S; Llorca, P M; Menezes, P R; Murray, R M; Quattrone, D; Rutten, B P; Sanjuán, J; Selten, J P; Szöke, A; Tarricone, I; Tortelli, A; Velthorst, E; de Haan, L; Schirmbeck, F.
Affiliation
  • Heuschen CBBCM; Amsterdam UMC, University of Amsterdam, Department of Psychiatry, Meibergdreef 5, 1105 AZ Amsterdam, the Netherlands. Electronic address: c.b.heuschen@amsterdamumc.nl.
  • Bolhuis K; Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC-Sophia Children's Hospital, Rotterdam, the Netherlands.
  • Zantvoord JB; Amsterdam UMC, University of Amsterdam, Department of Psychiatry, Meibergdreef 5, 1105 AZ Amsterdam, the Netherlands.
  • Bockting CL; Amsterdam UMC, University of Amsterdam, Department of Psychiatry, Meibergdreef 5, 1105 AZ Amsterdam, the Netherlands; Amsterdam Public Health Research Institute, Amsterdam UMC, University of Amsterdam, Meibergdreef 5, 1105 AZ Amsterdam, the Netherlands; Centre for Urban Mental Health, University of
  • Denys DAJP; Amsterdam UMC, University of Amsterdam, Department of Psychiatry, Meibergdreef 5, 1105 AZ Amsterdam, the Netherlands.
  • Lok A; Amsterdam UMC, University of Amsterdam, Department of Psychiatry, Meibergdreef 5, 1105 AZ Amsterdam, the Netherlands; Amsterdam Public Health Research Institute, Amsterdam UMC, University of Amsterdam, Meibergdreef 5, 1105 AZ Amsterdam, the Netherlands; Centre for Urban Mental Health, University of
  • Arango C; Institute of Psychiatry and Mental Health, Department of Child and Adolescent Psychiatry, Hospital General Universitario Gregorio Marañon, Universidad Complutense de Madrid, Spain.
  • Arrojo M; Department of Psychiatry, Psychiatric Genetic Group, Instituto de Investigación Sanitaria de Santiago de Compostela, Spain; Complejo Hospitalario Universitario de Santiago de Compostela, Servizo de Psiquiatría Santiago de Compostela, Galicia, Spain.
  • Bernardo M; Barcelona Clinic Schizophrenia Unit, Hospital Clinic of Barcelona, Department of Psychiatry and Psychology, Barcelona, Spain; Clinical Institute of Neuroscience, University of Barcelona, CIBERSAM, ISCIII, Barcelona, Spain.
  • Bobes J; Department of Medicine, Psychiatry Area, School of Medicine, Universidad de Oviedo, ISPA, INEUROPA, CIBERSAM, Oviedo, Spain.
  • Del-Ben CM; Neuroscience and Behavior Department, Ribeirão Preto Medical School, University of São Paulo, Campus de Ribeirao Preto, Ribeirao Preto, Brazil.
  • Di Forti M; Social Genetics and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, London, United Kingdom.
  • Gayer-Anderson C; Department of Health Services and Population Research, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; ESRC Centre for Society and Mental Health, King's College London, London, United Kingdom.
  • Jones PB; Department of Psychiatry, University of Cambridge, CAMEO, Cambridge shire & Peterborough NHS Foundation Trust, Cambridge, United Kingdom.
  • Jongsma HE; Centre for Transcultural Psychiatry 'Veldzicht', Balkbrug, the Netherlands; Psychosis Group, University Centre for Psychiatry, University Medical Centre Groningen, Groningen, the Netherlands.
  • Kirkbride JB; Division of Psychiatry, University College London, London, United Kingdom.
  • La Cascia C; Dept. Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Palermo, Italy.
  • Lasalvia A; Section of Psychiatry, Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
  • Tosato S; Section of Psychiatry, Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
  • Llorca PM; University Clermont Auvergne, CMP-B CHU, CNRS, Clermont Auvergne INP, Clermont-Ferrand, France; Institute Pascal, F-63000 Clermont-Ferrand, France.
  • Menezes PR; Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
  • Murray RM; Institute of Psychiatry, Psychology and Neuroscience, King's College, De Crespigny Park, London SE5 8AF, United Kingdom.
  • Quattrone D; Social Genetics and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; National Institute for Health Research (NIHR) Maudsley Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, King's College
  • Rutten BP; School for Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences Brain and Nerve Centre, Department of Psychiatry & Neuropsychology, Maastricht University, MUMC+, Maastricht, the Netherlands.
  • Sanjuán J; Faculty of Medicine, Psychiatry, Valencia, Spain.
  • Selten JP; School for Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences Brain and Nerve Centre, Department of Psychiatry & Neuropsychology, Maastricht University, MUMC+, Maastricht, the Netherlands; Rivierduinen Psychiatric Institute, Sandifortdreef 19, 2333 ZZ Leiden, the Nethe
  • Szöke A; Paris University Hospital Group for Psychiatry and Neurosciences, University Paris, Est Creteil, INSERM, IMRB, AP-HP, Hôpitaux Universitaires, DMU IMPACT, Fondation Fondamental, F-94010 Creteil, France.
  • Tarricone I; University of Bologna, Department of Medical and Surgical Sciences, Psychiatry Unit, Alma Mater Studiorum, Viale Pepoli 5, Bologna, Italy.
  • Tortelli A; Etablissement Public de Sante Maison Blanche, GHU Psychiatrie Neurosciences Paris, INSERM U-955, Paris, France.
  • Velthorst E; Community Mental Health Department, GGZ Noord-Holland-Noord, Heerhugowaard, the Netherlands.
  • de Haan L; Amsterdam UMC, University of Amsterdam, Department of Psychiatry, Meibergdreef 5, 1105 AZ Amsterdam, the Netherlands.
  • Schirmbeck F; Department of Public Mental Health, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Schizophr Res ; 270: 339-348, 2024 Jul 04.
Article in En | MEDLINE | ID: mdl-38968805
ABSTRACT

INTRODUCTION:

Suicidal ideation is common among individuals with first episode psychosis (FEP), with prevalence estimates up to 56.5 %. Despite its high prevalence, relatively little is known about how sociodemographic, clinical and/or developmental characteristics contribute to the experience of suicidal ideation in individuals with FEP.

METHODS:

In this cross-sectional study (FEP n = 551 and controls n = 857), univariate logistic regression analyses were performed to study the associations of sociodemographic, clinical, and developmental factors with suicidal ideation in individuals with FEP as well as controls. Suicidal ideation was assessed using the Community Assessment of Psychic Experiences (CAPE). In addition, multivariate logistic regression analyses were conducted based on a stepwise approach.

RESULTS:

In FEP, only depressive symptoms remained significantly associated with suicidal ideation when all correlates were integrated into one model. In the multivariate model in controls, depressive symptoms, positive symptoms, and traumatic childhood experiences were significantly associated with suicidal ideation.

CONCLUSIONS:

This study showed that depressive symptoms are an important factor relating to suicidal ideation in individuals with FEP, over and above other clinical, sociodemographic, and developmental factors. This underscores the relevance of screening for suicidal ideation in individuals with FEP, and highlights the need for a better understanding of the diagnostic uncertainty and course of mood symptoms in early psychosis.

LIMITATIONS:

Cross-sectional study design, self-reported questionnaires.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Schizophr Res Journal subject: PSIQUIATRIA Year: 2024 Document type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Schizophr Res Journal subject: PSIQUIATRIA Year: 2024 Document type: Article
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