Positive selection analysis of Cyt proteins from Bacillus thuringiensis: A conservative trend driven by negative (purifying) selection.
Toxicon
; 247: 107853, 2024 Aug 28.
Article
in En
| MEDLINE
| ID: mdl-38972359
ABSTRACT
Bacillus thuringiensis is a Gram-positive entomopathogenic bacterium that produces different pesticidal proteins vegetative insecticidal proteins (Vpb1/Vpa2, Vip3, and Vpb4) during vegetative growth, which are secreted to the culture medium, and δ-endotoxins (Cry and Cyt) during sporulation, which accumulate into parasporal crystals. Cyt proteins are the smaller subset of δ-endotoxins targeting Diptera species. While Cry and Vip3 proteins undergo positive selection, our analysis suggests that Cyt proteins evolve following a conservative trend driven negative (purifying) selection.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bacillus thuringiensis
/
Bacterial Proteins
/
Endotoxins
/
Bacillus thuringiensis Toxins
/
Hemolysin Proteins
Language:
En
Journal:
Toxicon
Year:
2024
Document type:
Article