Intracranial pressure monitoring in patients with spontaneous intracerebral hemorrhage: a systematic review with meta-analysis.

ABSTRACT

OBJECTIVE: To describe the potential effects of Intracranial pressure monitoring on the outcome of patients with spontaneous intracerebral hemorrhage. DESIGN: Systematic review with meta-analysis. SETTING: Observational and interventional studies published up to May 30th, 2024, were considered for inclusion. We investigated the effects of increased Intracranial pressure and intracranial pressure monitoring on relevant clinical outcomes. POPULATION Patients with spontaneous intracerebral hemorrhage treated with intracranial pressure monitoring. MAIN OUTCOME MEASURES: The primary outcome was mortality at 6 months and in-hospital mortality. The secondary outcome was poor neurological function outcome at 6 months. RESULTS: This analysis compares in-hospital and 6-month mortality rates between patients with intracranial pressure monitoring (ICPm) and those without (no ICPm). Although the ICPm group had a lower in-hospital mortality rate, it was not statistically significant (24.9% vs. 34.1%; OR 0.51, 95% CI 0.20 to 1.31, p=0.16). Excluding patients with intraventricular hemorrhage (IVH) revealed a significant reduction in in-hospital mortality for the ICPm group (23.5% vs. 43%; OR 0.39, 95% CI 0.29 to 0.53, p < 0.00001). For 6-month mortality, the ICPm group showed a significant reduction (32% vs. 39.6%; OR 0.76, 95% CI 0.61 to 0.94, p=0.01), with the effect being more pronounced after excluding IVH patients (29.1% vs. 47.2%; OR 0.45, 95% CI 0.34 to 0.60, p<0.0001). However, there were no statistically significant differences in 6-month functional outcomes between the groups. Increased ICP was associated with higher 3-month mortality (OR 1.12, 95% CI 1.07 to 1.18, p < 0.00001) and lower likelihood of good functional outcomes (OR 1.11, 95% CI 1.04 to 1.18, p < 0.00001). CONCLUSIONS: Elevated ICP is associated with increased mortality and poor prognosis in ICH patients. Although continuous intracranial pressure monitoring may reduce short-term mortality rates in specific subgroups of ICH patients, it does not improve neurological functional outcomes. While potential patient populations may benefit from ICP monitoring, more research is needed to screen suitable populations for ICP monitoring.