Silver/gold nanoalloy implant coatings with antibiofilm activity via pH-triggered silver ion release.
Chem Commun (Camb)
; 60(60): 7729-7732, 2024 Jul 23.
Article
in En
| MEDLINE
| ID: mdl-38973292
ABSTRACT
Implant infections are a major challenge for the healthcare system. Biofilm formation and increasing antibiotic resistance of common bacteria cause implant infections, leading to an urgent need for alternative antibacterial agents. In this study, the antibiofilm behaviour of a coating consisting of a silver (Ag)/gold (Au) nanoalloy is investigated. This alloy is crucial to reduce uncontrolled potentially toxic Ag+ ion release. In neutral pH environments this release is minimal, but the Ag+ ion release increases in acidic microenvironments caused by bacterial biofilms. We perform a detailed physicochemical characterization of the nanoalloys and compare their Ag+ ion release with that of pure Ag nanoparticles. Despite a lower released Ag+ ion concentration at pH 7.4, the antibiofilm activity against Escherichia coli (a bacterium known to produce acidic pH environments) is comparable to a pure nanosilver sample with a similar Ag-content. Finally, biocompatibility studies with mouse pre-osteoblasts reveal a decreased cytotoxicity for the alloy coatings and nanoparticles.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Silver
/
Biofilms
/
Alloys
/
Escherichia coli
/
Metal Nanoparticles
/
Gold
/
Anti-Bacterial Agents
Limits:
Animals
Language:
En
Journal:
Chem Commun (Camb)
Journal subject:
QUIMICA
Year:
2024
Document type:
Article
Affiliation country:
Suecia
Country of publication:
Reino Unido