Cardiac safety of ribociclib evaluated with 24-hour rhythm Holter electrocardiogram.
Support Care Cancer
; 32(8): 492, 2024 Jul 08.
Article
in En
| MEDLINE
| ID: mdl-38976108
ABSTRACT
OBJECTIVE:
We aimed to evaluate cardiac safety profile of ribociclib with 24-h rhythm Holter ECG. MATERIAL ANDMETHOD:
Forty-two female metastatic breast cancer patients were included in the study. Rhythm Holter ECG was performed before starting treatment with ribociclib and after 3 months of the treatment initiation.RESULTS:
The mean age of the patients was 56.36 ± 12.73. 52.4% (n = 22) of the patients were using ribociclib in combination with fulvestrant and 47.6% (n = 20) with aromatase inhibitors. None of the patients developed cardiotoxicity. When the rhythm Holter results before and in third month of the treatment were compared, there was no statistically significant difference.CONCLUSION:
This is the first study evaluating effects of ribociclib treatment on cardiac rhythm with Holter ECG. The findings suggested ribociclib has a low risk of causing early cardiotoxicity.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Purines
/
Breast Neoplasms
/
Electrocardiography, Ambulatory
/
Aminopyridines
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Middle aged
Language:
En
Journal:
Support Care Cancer
Journal subject:
NEOPLASIAS
/
SERVICOS DE SAUDE
Year:
2024
Document type:
Article
Affiliation country:
Turquía
Country of publication:
Alemania