Fragile Treg cells: Traitors in immune homeostasis?
Pharmacol Res
; 206: 107297, 2024 Aug.
Article
in En
| MEDLINE
| ID: mdl-38977207
ABSTRACT
Regulatory T (Treg) cells play a key role in maintaining immune tolerance and tissue homeostasis. However, in some disease microenvironments, Treg cells exhibit fragility, which manifests as preserved FoxP3 expression accompanied by inflammation and loss of immunosuppression. Fragile Treg cells are formatively, phenotypically and functionally diverse in various diseases, further complicating the role of Treg cells in the immunotherapeutic response and offering novel targets for disease treatment by modulating specific Treg subsets. In this review, we summarize findings on fragile Treg cells to provide a framework for characterizing the formation and role of fragile Treg cells in different diseases, and we discuss how this information may guide the development of more specific Treg-targeted immunotherapies.
Key words
(S)-Mepazine (PubChem CID: 7047380); EG01377 (PubChem CID: 133081972); Gallic acid (PubChem CID: 370); Galunisertib (PubChem CID: 10090485); HEROIN (PubChem CID: 5462328); Lactic acid (PubChem CID: 612); Morphine (PubChem CID: 5288826); Subasumstat (PubChem CID: 118628567); autoimmune disease; fragile Treg cell; immunotherapy; regulatory T cell; tumor microenvironment
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
T-Lymphocytes, Regulatory
/
Homeostasis
Limits:
Animals
/
Humans
Language:
En
Journal:
Pharmacol Res
Journal subject:
FARMACOLOGIA
Year:
2024
Document type:
Article
Country of publication:
Países Bajos