Thymopentin treatment in AIDS and pre-AIDS patients.
Surv Immunol Res
; 4 Suppl 1: 58-62, 1985.
Article
in En
| MEDLINE
| ID: mdl-3898293
ABSTRACT
Three pilot studies testing thymopentin in AIDS patients are presented. One study included 5 patients with the full-blown syndrome, all treated with 50 mg thymopentin 3 times a week by intravenous slow infusion; no immunologically nor clinically positive results were observed, indicating that the T cell pool in such patients is severely depleted. Six other patients with the prodromal stage of AIDS were treated 1 month with 50 mg thymopentin administered as an intravenous bolus injection 3 times weekly and thereafter for another month with same dose regimen as intravenous slow infusions. The patients on infusion therapy experienced statistically significant immunological improvements; these positive findings were paralleled with an improvement of the patients' clinical condition. These positive responses persisted for an average of 8 months. In another group of 5 pre-AIDS patients thymopentin was administered via the subcutaneous route using 15 mg 3 times weekly; only 1 patient revealed immunological and clinical improvement. In summary, only patients with the pre-AIDS syndrome are likely to benefit from immunomodulation therapy with thymopentin, and the mode of administration seems to be crucial.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Peptide Fragments
/
Thymopoietins
/
Thymus Hormones
/
Acquired Immunodeficiency Syndrome
Limits:
Humans
Language:
En
Journal:
Surv Immunol Res
Year:
1985
Document type:
Article