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NMR-Guided Isolation of Anti-inflammatory Carabranolides from the Fruits of Carpesium abrotanoides L.
Fu, Lu; Wang, Can-Can; Tian, Wenyue; Liu, Zhiyan; Bao, Meng-Yu; Liu, Jiazheng; Zhang, Wei; Bai, Li-Ping; Jiang, Zhi-Hong; Zhu, Guo-Yuan.
Affiliation
  • Fu L; State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR 999078, People's Republic of China.
  • Wang CC; State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR 999078, People's Republic of China.
  • Tian W; State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR 999078, People's Republic of China.
  • Liu Z; State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR 999078, People's Republic of China.
  • Bao MY; State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR 999078, People's Republic of China.
  • Liu J; State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR 999078, People's Republic of China.
  • Zhang W; State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR 999078, People's Republic of China.
  • Bai LP; State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR 999078, People's Republic of China.
  • Jiang ZH; State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR 999078, People's Republic of China.
  • Zhu GY; State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR 999078, People's Republic of China.
J Nat Prod ; 87(7): 1786-1797, 2024 Jul 26.
Article in En | MEDLINE | ID: mdl-38986603
ABSTRACT
Carabranolides present characteristic NMR resonances for the cyclopropane moiety, which distinctly differ from those of other compounds and were used for an NMR-guided isolation in this study. As a result, 11 undescribed carabranolides (1-11), along with five known ones (12-16), were isolated from the fruits of Carpesium abrotanoides L. Compounds 1-11 are new esters of carabrol at C-4 with different carboxylic acids. Their structures were elucidated by HRESIMS and NMR spectroscopic data analysis. The biological evaluation showed that compounds 2-4, 15, and 16 exhibited significant inhibitory activity against LPS-induced NO release with an IC50 value of 5.6-9.1 µM and dose-dependently decreased iNOS protein expression in RAW264.7 cells.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Asteraceae / Fruit / Anti-Inflammatory Agents / Nitric Oxide Limits: Animals Language: En Journal: J Nat Prod Year: 2024 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Asteraceae / Fruit / Anti-Inflammatory Agents / Nitric Oxide Limits: Animals Language: En Journal: J Nat Prod Year: 2024 Document type: Article