In the flow of molecular miniaturized fungal diagnosis.
Trends Biotechnol
; 2024 Jul 10.
Article
in En
| MEDLINE
| ID: mdl-38987118
ABSTRACT
The diagnosis of fungal infections presents several challenges and limitations, stemming from the similarities in symptomatology, diversity of underlying pathogenic species, complexity of fungal biology, and scarcity of rapid, affordable, and point-of-care approaches. In this review, we assess technological advances enabling the conversion of cutting-edge laboratory molecular diagnostic methods to cost-effective microfluidic devices. The most promising strategies toward the design of DNA sequence-based fungal diagnostic systems, capable of capturing and deciphering the highly informative DNA of the pathogen and adapted for resource-limited settings, are discussed, bridging fungal biology, molecular genetics, microfluidics, and biosensors.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Trends Biotechnol
Year:
2024
Document type:
Article
Affiliation country:
Portugal