The crosstalk between immune cells and tumor pyroptosis: advancing cancer immunotherapy strategies.
J Exp Clin Cancer Res
; 43(1): 190, 2024 Jul 10.
Article
in En
| MEDLINE
| ID: mdl-38987821
ABSTRACT
Pyroptosis is a cell death process characterized by cell swelling until membrane rupture and release of intracellular contents. As an effective tumor treatment strategy, inducing tumor cell pyroptosis has received widespread attention. In this process, the immune components within the tumor microenvironment play a key regulatory role. By regulating and altering the functions of immune cells such as cytotoxic T lymphocytes, natural killer cells, tumor-associated macrophages, and neutrophils, tumor cell pyroptosis can be induced. This article provides a comprehensive review of the molecular mechanisms of cell pyroptosis, the impact of the tumor immune microenvironment on tumor cell pyroptosis, and its mechanisms. It aims to gain an in-depth understanding of the communication between the tumor immune microenvironment and tumor cells, and to provide theoretical support for the development of new tumor immunotherapies.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pyroptosis
/
Immunotherapy
/
Neoplasms
Limits:
Animals
/
Humans
Language:
En
Journal:
J Exp Clin Cancer Res
Year:
2024
Document type:
Article
Affiliation country:
China