Efficacy and Safety of Long-term Ketogenic Diet Therapy in a Patient With Type 1 Diabetes.
JCEM Case Rep
; 2(7): luae102, 2024 Jul.
Article
in En
| MEDLINE
| ID: mdl-38989268
ABSTRACT
Fewer than 1% of patients with type 1 diabetes achieve normal glycemic control (glycated hemoglobin [HbA1c] < 5.7%/ < 39â
mmol/mol). Additionally, exogenous insulin administration often causes "iatrogenic hyperinsulinemia," leading to whole-body insulin resistance and increased risk of cardiovascular complications. We present data on the clinical efficacy and safety of a long-term (10-year) ketogenic diet (≤50â
g carbohydrates/day) therapy in a patient with type 1 diabetes. The use of a ketogenic diet resulted in successful glycemic control, assessed by HbA1c (5.5%; 36.6â
mmol/mol), continuous glucose monitoring median glucose (98â
mg/dL; 5.4â
mmol/L), and glucose time-in-range of 70 to 180â
mg/dL (90%) without acute glycemic complications. In conjunction, there was a 43% decrease in daily insulin requirements. Low-density lipoprotein cholesterol increased, whereas small-dense low-density lipoprotein was in the normal range (<90â
nmol/L). No adverse effects were observed on thyroid function, kidney function, or bone mineral density. This case report demonstrates that a long-term ketogenic diet in a person with type 1 diabetes has considerable therapeutic benefits.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
JCEM Case Rep
Year:
2024
Document type:
Article
Affiliation country:
Estados Unidos