Part II: A new perspective for modeling the bone remodeling process: Biology, mechanics, and pathologies.
J Theor Biol
; 593: 111894, 2024 10 07.
Article
in En
| MEDLINE
| ID: mdl-38992463
ABSTRACT
In this paper, we explore the effects of biological (pathological) and mechanical damage on bone tissue within a benchmark model. Using the Finite Element Methodology, we analyze and numerically test the model's components, capabilities, and performance under physiologically and pathologically relevant conditions. Our findings demonstrate the model's effectiveness in simulating bone remodeling processes and self-repair mechanisms for micro-damage induced by biological internal conditions and mechanical external ones within bone tissue. This article is the second part of a series, where the first part presented the mathematical model and the biological and physical significance of the terms used in a simplified benchmark model. It explored the bone remodeling model's application, implementation, and results under physiological conditions.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bone Remodeling
/
Models, Biological
Limits:
Animals
/
Humans
Language:
En
Journal:
J Theor Biol
Year:
2024
Document type:
Article
Country of publication:
Reino Unido