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From biogenesis to aptasensors: advancements in analysis for tumor-derived extracellular vesicles research.
Yang, Gaojian; Li, Zhiyang; Usman, Rabia; Liu, Yuan; Li, Song; Chen, Zhu; Chen, Hui; Deng, Yan; Fang, Yile; He, Nongyue.
Affiliation
  • Yang G; State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.
  • Li Z; Department of Clinical Laboratory, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China.
  • Usman R; State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.
  • Liu Y; Institute of Cytology and Genetics, School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hengyang 421001, China.
  • Li S; Institute for Future Sciences, University of South China, Changsha Hunan 410000, China.
  • Chen Z; Institute of Cytology and Genetics, School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hengyang 421001, China.
  • Chen H; Institute for Future Sciences, University of South China, Changsha Hunan 410000, China.
  • Deng Y; China Hunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of Technology, Zhuzhou 412007, PR China.
  • Fang Y; Institute of Cytology and Genetics, School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hengyang 421001, China.
  • He N; Institute for Future Sciences, University of South China, Changsha Hunan 410000, China.
Theranostics ; 14(10): 4161-4183, 2024.
Article in En | MEDLINE | ID: mdl-38994022
ABSTRACT
Extracellular vesicles (EVs) are enclosed by a nanoscale phospholipid bilayer membrane and typically range in size from 30 to 200 nm. They contain a high concentration of specific proteins, nucleic acids, and lipids, reflecting but not identical to the composition of the parent cell. The inherent characteristics and variety of EVs give them extensive and unique advantages in the field of cancer identification and treatment. Recently, EVs have been recognized as potential tumor markers for the detection of cancer. Aptamers, which are molecules of single-stranded DNA or RNA, demonstrate remarkable specificity and affinity for their targets by adopting distinct tertiary structures. Aptamers offer various advantages over their protein counterparts, such as reduced immunogenicity, the ability for convenient large-scale synthesis, and straightforward chemical modification. In this review, we summarized EVs biogenesis, sample collection, isolation, storage and characterization, and finally provided a comprehensive survey of analysis techniques for EVs detection that are based on aptamers.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aptamers, Nucleotide / Extracellular Vesicles / Neoplasms Limits: Animals / Humans Language: En Journal: Theranostics Year: 2024 Document type: Article Affiliation country: China Country of publication: Australia

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aptamers, Nucleotide / Extracellular Vesicles / Neoplasms Limits: Animals / Humans Language: En Journal: Theranostics Year: 2024 Document type: Article Affiliation country: China Country of publication: Australia