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Purine-Rich Element Binding Protein Alpha, a Nuclear Matrix Protein, Has a Role in Prostate Cancer Progression.
Inoue, Takahiro; Bao, Xin; Kageyama, Takumi; Sugino, Yusuke; Sekito, Sho; Miyachi, Shiori; Sasaki, Takeshi; Getzenberg, Robert.
Affiliation
  • Inoue T; Department of Nephro-Urologic Surgery and Andrology, Mie University Graduate School of Medicine, 2-174, Edobashi, Tsu 514-0001, Japan.
  • Bao X; Department of Nephro-Urologic Surgery and Andrology, Mie University Graduate School of Medicine, 2-174, Edobashi, Tsu 514-0001, Japan.
  • Kageyama T; Department of Nephro-Urologic Surgery and Andrology, Mie University Graduate School of Medicine, 2-174, Edobashi, Tsu 514-0001, Japan.
  • Sugino Y; Department of Nephro-Urologic Surgery and Andrology, Mie University Graduate School of Medicine, 2-174, Edobashi, Tsu 514-0001, Japan.
  • Sekito S; Department of Nephro-Urologic Surgery and Andrology, Mie University Graduate School of Medicine, 2-174, Edobashi, Tsu 514-0001, Japan.
  • Miyachi S; Department of Nephro-Urologic Surgery and Andrology, Mie University Graduate School of Medicine, 2-174, Edobashi, Tsu 514-0001, Japan.
  • Sasaki T; Department of Nephro-Urologic Surgery and Andrology, Mie University Graduate School of Medicine, 2-174, Edobashi, Tsu 514-0001, Japan.
  • Getzenberg R; Dr. Kiran C Patel College of Allopathic Medicine, Nova Southeastern University, Fort Lauderdale, FL 33328, USA.
Int J Mol Sci ; 25(13)2024 Jun 24.
Article in En | MEDLINE | ID: mdl-39000020
ABSTRACT
Solid tumors as well as leukemias and lymphomas show striking changes in nuclear structure including nuclear size and shape, the number and size of nucleoli, and chromatin texture. These alterations have been used in cancer diagnosis and might be related to the altered functional properties of cancer cells. The nuclear matrix (NM) represents the structural composition of the nucleus and consists of nuclear lamins and pore complexes, an internal ribonucleic protein network, and residual nucleoli. In the nuclear microenvironment, the NM is associated with multi-protein complexes, such as basal transcription factors, signaling proteins, histone-modifying factors, and chromatin remodeling machinery directly or indirectly through scaffolding proteins. Therefore, alterations in the composition of NM could result in altered DNA topology and changes in the interaction of various genes, which could then participate in a cascade of the cancer process. Using an androgen-sensitive prostate cancer cell line, LNCaP, and its androgen-independent derivative, LN96, conventional 2D-proteomic analysis of the NM proteins revealed that purine-rich element binding protein alpha (PURα) was detected in the NM proteins and differentially expressed between the cell lines. In this article, we will review the potential role of the molecule in prostate cancer.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Neoplasms Limits: Animals / Humans / Male Language: En Journal: Int J Mol Sci Year: 2024 Document type: Article Affiliation country: Japón Country of publication: Suiza

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Neoplasms Limits: Animals / Humans / Male Language: En Journal: Int J Mol Sci Year: 2024 Document type: Article Affiliation country: Japón Country of publication: Suiza