The Role of Prefrontal Ensembles in Memory Across Time: Time-Dependent Transformations of Prefrontal Memory Ensembles.
Adv Neurobiol
; 38: 67-78, 2024.
Article
in En
| MEDLINE
| ID: mdl-39008011
ABSTRACT
The medial prefrontal cortex (mPFC) plays a critical role in recalling recent and remote fearful memories. Modern neuroscience techniques, such as projection-specific circuit manipulation and activity-dependent labeling, have illuminated how mPFC memory ensembles are reorganized over time. This chapter discusses the implications of new findings for traditional theories of memory, such as the systems consolidation theory and theories of memory engrams. It also examines the specific contributions of mPFC subregions, like the prelimbic and infralimbic cortices, in fear memory, highlighting how their distinct connections influence memory recall. Further, it elaborates on the cellular and molecular changes within the mPFC that support memory persistence and how these are influenced by interactions with the hippocampus. Ultimately, this chapter provides insights into how lasting memories are dynamically encoded in prefrontal circuits, arguing for a key role of memory ensembles that extend beyond strict definitions of the engram.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Prefrontal Cortex
/
Fear
/
Hippocampus
/
Memory
Limits:
Animals
/
Humans
Language:
En
Journal:
Adv Neurobiol
Year:
2024
Document type:
Article
Affiliation country:
Estados Unidos