Further evidence of the role of microRNA in schizophrenia: a case report.
Psychiatr Genet
; 34(5): 111-114, 2024 Oct 01.
Article
in En
| MEDLINE
| ID: mdl-39011718
ABSTRACT
According to the neurodevelopmental hypothesis of schizophrenia, genetic predisposing factors cause abnormalities in neural functions, leading to the disease. A 2-year follow-up of a young woman with schizophrenia is presented. Karyotype, Affymetrix CytoScan TM 750K SNP array, and optical genome mapping ultra-high molecular weight were carried out. The case presented a severe and resistant to treatment schizophrenia. A 404â
kbp microduplication in 2q13 (chr2â
â
112088944-112492811; Hg19) was revealed, which includes an only gene ( MIR4435-2HG , OMIM 617144). The Positive and Negative Syndrome Scale of Schizophrenia questionnaire showed a moderate improvement after 2 years, but functioning was still poor. The presented case had a microduplication of copy number variants at 2q13, previously linked to schizophrenia, but it only involved one gene, encoding a microRNA, which regulates the expression of candidate genes associated to neurodevelopment. This case provides further evidence of the importance of microRNA in the pathogenesis of schizophrenia.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Schizophrenia
/
MicroRNAs
Limits:
Adult
/
Female
/
Humans
Language:
En
Journal:
Psychiatr Genet
Journal subject:
GENETICA
/
PSIQUIATRIA
Year:
2024
Document type:
Article
Country of publication:
Reino Unido