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Pre-pandemic Metabolic Correlates of COVID-19 Severity and Long COVID Incidence in People Living with HIV.
Agrawal, Priyesh; Giron, Leila B; Singh, Shalini; Haw, Nel Jason; Goldman, Aaron R; Elkaeid, Mohammed; Macatangay, Bernard; Palella, Frank J; Alcaide, Maria L; Moran, Caitlin A; Kassaye, Seble G; Erdmann, Nathan; Chew, Kara W; Floris-Moore, Michelle; Chandran, Aruna; Augenbraun, Michael H; Sharma, Anjali; Palmer, Clovis; Landay, Alan L; Peluso, Michael J; Keshavarzian, Ali; Brown, Todd T; Tien, Phyllis C; Abdel-Mohsen, Mohamed.
Affiliation
  • Agrawal P; Adaptive Phage Therapeutics, Gaithersburg, MD, USA.
  • Giron LB; The Wistar Institute, Philadelphia, PA, USA.
  • Singh S; The Wistar Institute, Philadelphia, PA, USA.
  • Haw NJ; Johns Hopkins University, Baltimore, MD, USA.
  • Goldman AR; The Wistar Institute, Philadelphia, PA, USA.
  • Elkaeid M; The Wistar Institute, Philadelphia, PA, USA.
  • Macatangay B; University of Pittsburgh, Pittsburgh, PA, USA.
  • Palella FJ; Northwestern University, Chicago, IL, USA.
  • Alcaide ML; University of Miami Miller School of Medicine, Miami, FL, USA.
  • Moran CA; Emory University, Atlanta, GA, USA.
  • Kassaye SG; Georgetown University, Washington, DC, USA.
  • Erdmann N; University of Alabama at Birmingham, Birmingham, AL, USA.
  • Chew KW; University of California Los Angeles, Los Angeles, CA, USA.
  • Floris-Moore M; University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Chandran A; Johns Hopkins University, Baltimore, MD, USA.
  • Augenbraun MH; SUNY Downstate Health Sciences University, Brooklyn, NY, USA.
  • Sharma A; Albert Einstein College of Medicine, Bronx, NY, USA.
  • Palmer C; Tulane National Primate Research Center, Covington, LA, USA.
  • Landay AL; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA.
  • Peluso MJ; Department of Medicine, Rush University, Chicago, IL, USA.
  • Keshavarzian A; University of California San Francisco, San Francisco, CA, USA.
  • Brown TT; Department of Medicine, Rush University, Chicago, IL, USA.
  • Tien PC; Rush Center for Integrated Microbiome and Chronobiology Research, Rush University, Chicago, IL, USA.
  • Abdel-Mohsen M; Johns Hopkins University, Baltimore, MD, USA.
J Infect Dis ; 2024 Jul 16.
Article in En | MEDLINE | ID: mdl-39011957
ABSTRACT
Host metabolic dysregulation, especially in tryptophan metabolism, is intricately linked to COVID-19 severity and its post-acute sequelae (Long COVID). People living with HIV (PLWH) experience similar metabolic dysregulation and face an increased risk of developing Long COVID. However, whether pre-existing HIV-associated metabolic dysregulations contribute in predisposing PLWH to severe COVID-19 outcomes remains underexplored. Analyzing pre-pandemic samples from PLWH with documented post-infection outcomes, we found specific metabolic alterations, including increased tryptophan catabolism, predicting an elevated risk of severe COVID-19 and the incidence of Long COVID. These alterations warrant further investigation for their potential prognostic and mechanistic significance in determining COVID-19 complications.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: J Infect Dis Year: 2024 Document type: Article Affiliation country: Estados Unidos
Fulltext
Add to My VHL
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: J Infect Dis Year: 2024 Document type: Article Affiliation country: Estados Unidos