Primary Sjögren's syndrome: new perspectives on salivary gland epithelial cells.
Eur J Med Res
; 29(1): 371, 2024 Jul 17.
Article
in En
| MEDLINE
| ID: mdl-39014509
ABSTRACT
Primary Sjögren's syndrome (pSS) is a chronic autoimmune disease primarily affecting exocrine glands such as the salivary glands, leading to impaired secretion and sicca symptoms. As the mainstay of salivation, salivary gland epithelial cells (SGECs) have an important role in the pathology of pSS. Emerging evidence suggests that the interplay between immunological factors and SGECs may not be the initial trigger or the sole mechanism responsible for xerostomia in pSS, challenging conventional perceptions. To deepen our understanding, current research regarding SGECs in pSS was reviewed. Among the extensive aberrations in cellular architecture and function, this review highlighted certain alterations of SGECs that were identified to occur independently of or in absence of lymphocytic infiltration. In particular, some of these alterations may serve as upstream factors of immuno-inflammatory responses. These findings underscore the significance of introspecting the pathogenesis of pSS and developing interventions targeting SGECs in the early stages of the disease.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Salivary Glands
/
Sjogren's Syndrome
/
Epithelial Cells
Limits:
Humans
Language:
En
Journal:
Eur J Med Res
Journal subject:
MEDICINA
Year:
2024
Document type:
Article
Affiliation country:
China