Antibiotics, passive smoking, high socioeconomic status and sweetened foods contribute to the risk of paediatric inflammatory bowel disease: A systematic review with meta-analysis.
J Pediatr Gastroenterol Nutr
; 2024 Jul 17.
Article
in En
| MEDLINE
| ID: mdl-39020449
ABSTRACT
OBJECTIVE:
Genetic and environmental factors influence pathogenesis and rising incidence of paediatric inflammatory bowel disease (PIBD). The aim was to meta-analyse evidence of diet and environmental factors in PIBD.METHODS:
A systematic search was conducted to identify diet and environmental factors with comparable risk outcome measures and had been reported in two or more PIBD studies for inclusion in meta-analyses. Those with ≥2 PIBD risk estimates were combined to provide pooled risk estimates.RESULTS:
Of 4763 studies identified, 36 studies were included. PIBD was associated with higher risk with exposure to ≥/=4 antibiotic courses (includes prescriptions/purchases/courses), passive smoking, not being breastfed, sugary drink intake, being a non-Caucasian child living in a high-income country and infection history (odds ratio [OR] range 2-3.8). Paediatric Crohn's disease (CD) was associated with higher risk with exposure to antibiotics during early childhood, ≥/=4 antibiotic courses, high socioeconomic status (SES), maternal smoking, history of atopic conditions and infection history (OR range 1.6-4.4). A history of infection was also associated with higher risk of paediatric ulcerative colitis (UC) (OR 3.73). Having a higher number of siblings (≥2) was associated with lower risk of paediatric CD (OR 0.6) and paediatric UC (OR 0.7). Pet exposure was associated with lower risk of paediatric UC (OR 0.5).CONCLUSION:
Several factors associated with PIBD risk were identified that could potentially be used to develop a disease screening tool. Future research is needed to address risk reduction in PIBD.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
J Pediatr Gastroenterol Nutr
Year:
2024
Document type:
Article
Affiliation country:
Australia