PDCD2 as a prognostic biomarker in glioma correlates with malignant phenotype.
Genes Dis
; 11(5): 101106, 2024 Sep.
Article
in En
| MEDLINE
| ID: mdl-39022129
ABSTRACT
Programmed cell death 2 (PDCD2) is related to cancer progression and chemotherapy sensitivity. The role of PDCD2 in solid cancers (excluding hematopoietic malignancies) and their diagnosis and prognosis remains unclear. The TCGA, CGGA, GEPIA, cBioPortal, and GTEx databases were analyzed for expression, prognostic value, and genetic modifications of PDCD2 in cancer patients. Functional enrichment analysis, CCK8, colony formation assay, transwell assay, and xenograft tumor model were undertaken to study the PDCD2's biological function in glioma (GBMLGG). The PDCD2 gene was associated with solid cancer progression. In the functional enrichment analysis results, PDCD2 was shown to participate in several important GBMLGG biological processes. GBMLGG cells may be inhibited in their proliferation, migration, invasion, and xenograft tumor growth by knocking down PDCD2. Our research can provide new insights into solid cancer prognostic biomarkers of PDCD2.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Genes Dis
Year:
2024
Document type:
Article
Affiliation country:
China