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Tumor-infiltrating lymphocytes: A new hope.
Sarnaik, Amod A; Hwu, Patrick; Mulé, James J; Pilon-Thomas, Shari.
Affiliation
  • Sarnaik AA; Immunology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA; Cutaneous Oncology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA. Electronic address: amod.sarnaik@moffitt.org.
  • Hwu P; Immunology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA; Cutaneous Oncology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
  • Mulé JJ; Immunology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA; Cutaneous Oncology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
  • Pilon-Thomas S; Immunology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA; Center for Immunization and Infection Research in Cancer, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Cancer Cell ; 42(8): 1315-1318, 2024 Aug 12.
Article in En | MEDLINE | ID: mdl-39029463
ABSTRACT
Tumor-infiltrating lymphocytes (TILs) can be massively expanded from resected tumors and used as a cellular treatment for advanced malignancies. TILs require a preparative non-myeloablative chemotherapy followed by an abbreviated course of interleukin-2. Here, we review the historical development of TIL therapy and discuss potential solutions to ongoing roadblocks that may result in broader and improved efficacy for patients afflicted with treatment-refractory, advanced cancer.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lymphocytes, Tumor-Infiltrating / Neoplasms Limits: Animals / Humans Language: En Journal: Cancer Cell / Cancer cell Journal subject: NEOPLASIAS Year: 2024 Document type: Article Country of publication: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lymphocytes, Tumor-Infiltrating / Neoplasms Limits: Animals / Humans Language: En Journal: Cancer Cell / Cancer cell Journal subject: NEOPLASIAS Year: 2024 Document type: Article Country of publication: Estados Unidos