Exploring the role of environmental enrichment and early life adversity on emotional development.
Behav Brain Res
; 472: 115147, 2024 08 24.
Article
in En
| MEDLINE
| ID: mdl-39029628
ABSTRACT
Early life adversity has been linked with a higher probability of developing behavioral impairments and environmental manipulation is a strategy that may reduce the negative effects of exposure to adversity in early life. Here, we focused on exploring the influence of environmental enrichment (EE) as a protective factor in the context of early life adversity. We hypothesized that 24â¯hours of maternal deprivation (MD), in the second week of life, could induce anxiety-like behavior alterations and that exposure to EE could induce resilience to these behaviors due to alterations in the serotonergic system. Male Wistar rats were exposed to MD, on postnatal days 11 and 13, and to EE, after weaning. In adulthood, we performed a series of behavioral tests for fear, anxiety, and locomotor activity. We also measured the levels of serotonin in the amygdala and dorsal raphe nucleus. Our results revealed that MD does not impact fear behavior or the levels of serotonin, while EE decreases locomotor activity in a novel environment and enhances exploration in the predator odor test. EE also decreases serotonin in the amygdala and increases its turnover rate levels. Our findings provide insights into the critical timeframe during which stress exposure impacts the development and confirm that exposure to EE has an independent and protective effect for anxiety-like behaviors later in life.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Emotions
/
Environment
/
Adverse Childhood Experiences
Limits:
Animals
Language:
En
Journal:
Behav Brain Res
Year:
2024
Document type:
Article
Country of publication:
Países Bajos