Mechanisms of DNA Damage Response in Mammalian Oocytes.
Adv Anat Embryol Cell Biol
; 238: 47-68, 2024.
Article
in En
| MEDLINE
| ID: mdl-39030354
ABSTRACT
DNA damage poses a significant challenge to all eukaryotic cells, leading to mutagenesis, genome instability and senescence. In somatic cells, the failure to repair damaged DNA can lead to cancer development, whereas, in oocytes, it can lead to ovarian dysfunction and infertility. The response of the cell to DNA damage entails a series of sequential and orchestrated events including sensing the DNA damage, activating DNA damage checkpoint, chromatin-related conformational changes, activating the DNA damage repair machinery and/or initiating the apoptotic cascade. This chapter focuses on how somatic cells and mammalian oocytes respond to DNA damage. Specifically, we will discuss how and why fully grown mammalian oocytes differ drastically from somatic cells and growing oocytes in their response to DNA damage.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Oocytes
/
DNA Damage
/
DNA Repair
Limits:
Animals
/
Female
/
Humans
Language:
En
Journal:
Adv Anat Embryol Cell Biol
Year:
2024
Document type:
Article
Affiliation country:
Estados Unidos
Country of publication:
Alemania