Retrospective study of risk markers for developing high-grade anal intraepithelial neoplasm in men who have sex with men living with HIV. / Estudio retrospectivo que evalúa marcadores de riesgo de desarrollar lesión escamosa intraepitelial anal de alto grado en hombres que tiene sexo con hombres y viven con el virus de inmunodeficiencia humana.
Actas Dermosifiliogr
; 2024 Jul 18.
Article
in En, Es
| MEDLINE
| ID: mdl-39032782
ABSTRACT
High-grade anal intraepithelial squamous lesion is significantly prevalent among men who have sex with men and are infected with the human immunodeficiency virus. This condition-the precursor to anal cancer-significantly increases the risk of developing it. Conversely, low-grade anal intraepithelial squamous typically follow a benign course and usually regress spontaneously. MATERIALS AND METHODS:
To describe a population of men who have sex with men living with human immunodeficiency virus followed in a specialized anal cancer screening unit we conducted an observational, retrospective, and single-center study was.RESULTS:
Ninety-four patients were analyzed, with a mean age of 39 ± 9 years, and a 87% positivity rate for high-risk human papillomavirus (HR-HPV). At the initial visit, 47% presented with low-grade squamous intraepithelial lesions. The progression rate to high-grade squamous intraepithelial lesion was 37.2 per 100,000 patients/year. None of the patients developed anal cancer. Tobacco and alcohol consumption were associated with this progression.DISCUSSION:
In this series, longer duration of HIV infection, tobacco and alcohol use and the presence of HR-HPV were significantly associated with the occurrence of high-grade intraepithelial lesions. A lower risk of progression was seen in patients with higher education.CONCLUSION:
In men who have sex with men living with HIV, the association of factors such as smoking, alcohol, the presence of HR-HPV and an increased burden of human papillomavirus disease makes these patients more susceptible to develop high-grade anal squamous lesions.
Human Immunodeficiency Virus; Human Papillomavirus Virus; Squamous Intraepithelial lesion; anal canal; anal intraepithelial neoplasm; canal anal; condiloma; condyloma; hombres que tienen sexo con hombres; lesión escamosa intraepitelial anal; men who have sex with men; neoplasia intraepitelial anal; virus de inmunodeficiencia humana; virus del papiloma humano
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01-internacional
Database:
MEDLINE
Language:
En
/
Es
Journal:
Actas Dermosifiliogr
Year:
2024
Document type:
Article