Guaianolide sesquiterpene lactones from Cichorium glandulosum and their anti-neuroinflammation activities.
Phytochemistry
; 226: 114223, 2024 Jul 19.
Article
in En
| MEDLINE
| ID: mdl-39032793
ABSTRACT
Eight undescribed guaianolide sesquiterpene lactones cicholosumins A-H and twelve known ones were isolated from the aerial parts of Cichorium glandulosum Boiss et Huet. Their structures were established by 1D and 2D NMR spectroscopic data, electronic circular dichroism, quantum chemical calculations and single crystal X-ray diffraction analysis. Compounds 9α-hydroxy-3-deoxyzaluzanin C, epi-8α-angeloyloxycichoralexin, 8-O-methylsenecioylaustricin and lactucin showed strong anti-neuroinflammation activity with IC50 values of 1.69 ± 0.11, 1.08 ± 0.23, 1.67 ± 0.28 and 1.82 ± 0.27 µM, respectively. The mechanism research indicated that epi-8α-angeloyloxycichoralexin inhibited neuroinflammation through the NF-κB and MAPK pathways.
Full text:
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Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Phytochemistry
Year:
2024
Document type:
Article