4-Hydroxyphenylpyruvate Dioxygenase Inhibitors: From Molecular Design to Synthesis.
J Agric Food Chem
; 72(31): 17125-17137, 2024 Aug 07.
Article
in En
| MEDLINE
| ID: mdl-39047218
ABSTRACT
Weed resistance is a critical issue in crop production. Among the known herbicides, 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitors are crucial for addressing weed resistance. HPPD inhibitors constitute a pivotal aspect of contemporary crop protection strategies. The advantages of these herbicides are their broad weed spectrum, flexible application, and excellent compatibility with other herbicides. They also exhibit satisfactory crop selectivity and low toxicity and are environmentally friendly. An increasing number of new HPPD inhibitors have been designed by combining computer-aided drug design with conventional design approaches. Herein, the molecular design and structural features of innovative HPPD inhibitors are reviewed to guide the development of new HPPD inhibitors possessing an enhanced biological efficacy.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Drug Design
/
Enzyme Inhibitors
/
Plant Weeds
/
Herbicides
/
4-Hydroxyphenylpyruvate Dioxygenase
Language:
En
Journal:
J Agric Food Chem
/
J. agric. Food chem
/
Journal of agricultural and food chemistry
Year:
2024
Document type:
Article
Affiliation country:
China
Country of publication:
Estados Unidos