Enzoology: understanding enzyme interactions and epistasis in the cell.
Trends Biochem Sci
; 49(10): 841-842, 2024 Oct.
Article
in En
| MEDLINE
| ID: mdl-39048479
ABSTRACT
Recent work from Nguyen et al. unveils massively parallel measurements of epistatic interactions between two enzymes, dihydrofolate reductase and thymidylate synthase, in their natural cellular context. Almost 3000 mutations of DHFR in three TYMS backgrounds reveal a complex interaction network. The authors capture much of this complexity using a simple model.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tetrahydrofolate Dehydrogenase
/
Thymidylate Synthase
/
Epistasis, Genetic
Limits:
Humans
Language:
En
Journal:
Trends Biochem Sci
Year:
2024
Document type:
Article
Country of publication:
Reino Unido