How c-di-GMP controls progression through the Streptomyces life cycle.
Curr Opin Microbiol
; 80: 102516, 2024 Aug.
Article
in En
| MEDLINE
| ID: mdl-39059031
ABSTRACT
Members of the antibiotic-producing bacterial genus Streptomyces undergo a complex developmental life cycle that culminates in the production of spores. Central to control of this cell differentiation process is signaling through the second messenger 3', 5'-cyclic diguanylic acid (c-di-GMP). So far, three proteins that are directly controlled by c-di-GMP in Streptomyces have been functionally and structurally characterized the key developmental regulators BldD and σWhiG, and the glycogen-degrading enzyme GlgX. c-di-GMP signals through BldD and σWhiG, respectively, to control the two most dramatic transitions of the Streptomyces life cycle, the formation of the reproductive aerial hyphae and their differentiation into spore chains. Later in development, c-di-GMP activates GlgX-mediated degradation of glycogen, releasing stored carbon for spore maturation.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Spores, Bacterial
/
Streptomyces
/
Bacterial Proteins
/
Gene Expression Regulation, Bacterial
/
Cyclic GMP
Language:
En
Journal:
Curr Opin Microbiol
Journal subject:
MICROBIOLOGIA
Year:
2024
Document type:
Article
Affiliation country:
Estados Unidos
Country of publication:
Reino Unido