The Potential Role of PSMA-Targeted PET in Salivary Gland Malignancies: An Updated Systematic Review.
Diagnostics (Basel)
; 14(14)2024 Jul 14.
Article
in En
| MEDLINE
| ID: mdl-39061653
ABSTRACT
BACKGROUND:
Recent studies have suggested using positron emission tomography/computed tomography (PET/CT) with prostate-specific membrane antigen (PSMA)-targeting radiopharmaceuticals for the detection of salivary gland malignancies (SGM), particularly adenoid-cystic carcinoma (ACC).METHODS:
The authors conducted an extensive review of the scientific literature to examine the potential diagnostic role of PET/CT using PSMA-targeting radiopharmaceuticals in salivary gland malignancies (SGMs) and adenoid cystic carcinoma (ACC). This study included newly diagnosed SGM patients and those with disease recurrence in their imaging evaluation.RESULTS:
This updated systematic review included a total of six studies that examined the diagnostic performance of PSMA-targeted PET/CT in ACC. The articles provided evidence of a high detection rate of PSMA-targeting PET/CT in ACC across all clinical contexts examined. SGMs other than ACC exhibited poorer diagnostic performance.CONCLUSIONS:
PSMA-targeted PET/CT seems promising in detecting ACC lesions; moreover, PSMA appears to be a suitable potential target for radioligand therapy. Prospective multicentric studies are warranted to strengthen the role of PSMA-targeting radiopharmaceuticals in ACC, as both diagnostic and theragnostic agents.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Diagnostics (Basel)
Year:
2024
Document type:
Article
Affiliation country:
Italia
Country of publication:
Suiza